The ideal of cancer therapy is to promote apoptosis of cancer cells. Traditional chemotherapeutic agents (first generation indirect apoptogens) trigger events which result in apoptosis of cancer cells.

Dallas, TX -- (SBWIRE) -- 04/07/2010 -- Biotech-Market-Reports Announce it Will Carry the Apoptosis 2009 Opportunities in Cancer and Other Diseases Market Research Report in its Store.

Browse the complete Report on: http://www.biotech-market-reports.com/market-reports/apoptosis-2009-opportunities-in-cancer-and-other-diseases/

Market background

The main application of apoptosis research is presently in cancer treatment. It should be noted that this market is one of the largest and fastest growing sectors of the pharma industry. Of the 370 pipeline agents identified in Apoptosis 2009: Opportunities in Cancer and Other Diseases, 80% are anticancers. This report segments the apoptosis-related cancer market into: direct apoptogens (apoptosis-inducing drugs known, during their development, to have apoptosis-related molecular targets)
a. first generation indirect apoptogens (established drugs such as cytotoxics which have turned out to rely on apoptosis for part of their efficacy)
b. second generation indirect apoptogens (recently introduced and pipeline drugs with non-apoptotic targets which nevertheless have apoptotic effects).
c. Opportunities for apoptosis modulators in indications such as CNS disorders and chronic inflammation/autoimmunity are also explored.

Key Features

Examination of the molecular events in apoptosis which may become dysregulated, providing opportunities for therapeutic intervention.
• Description of morphological criteria for detecting apoptosis, as well as recent methodologies based on detecting specific biological aspects and biomarkers.
• Analysis of 370 apoptosis-modulating drug candidates (9% in Phase 3 or later) from 233 originating companies. These drugs target 148 known gene targets, of which the top 15 are shown in Figure 1.3 from the report, as reproduced below.
• Deployment of Stanford Research Institute's PANTHER Classification System to identify gene targets with a validated role in apoptosis.
• Analysis of 4,872 apoptosis-related patents and patent applications to identify technology trends and potential therapeutic applications.
• Forecasts for the overall oncology-based apoptosis market, and its individual sectors.

Key Benefits

Utilize biomarker and drug target information in this report to discover and develop drugs with apoptosis-modulating properties.
• Identify emerging areas of opportunity for apoptosis modulators in cancer, CNS diseases, and chronic inflammation/autoimmunity.
• Gain up-to-date competitive intelligence on apoptosis-modulating pipelines and identify the most promising drugs under development.
• Identify the leading originator companies developing apoptosis-modulating drugs.
Use the patent analysis presented in this report to identify leading assignees, most influential patents and unexploited indications for apoptosis modulation.
• Devise a commercial strategy leveraging apoptosis by utilizing market forecasts for the oncology-based apoptosis market to 2013.

Key Issues raised

The ideal of cancer therapy is to promote apoptosis of cancer cells. Traditional chemotherapeutic agents (first generation indirect apoptogens) trigger events which result in apoptosis of cancer cells. However, they also kill normal cells. Second generation indirect apoptogens may be less toxic to normal cells.
• Wide prevalence of indirect apoptotic effects suggests that it is always worth screening for apoptotic effects of new anticancer drugs. Wider application of validated biomarkers of apoptosis in preclinical and clinical trials of new drugs is thus highly desirable.
• The utility of current anticancer therapies is limited by drug resistance, either intrinsic or acquired. Direct apoptogens target overexpressed anti-apoptotic proteins or downregulated pro-apoptotic proteins responsible for therapy resistance.
• Neurodegenerative diseases represent an area of unmet clinical need. No therapy for neuroprotection is currently marketed, but new apoptosis-modulating drugs in development show promise.
• Existing treatments for rheumatoid arthritis and other autoimmune conditions (anti-TNF therapies and glucocorticoids) may act partly via apoptosis modulation. However, new apoptosis- modulating therapies with improved specificity are needed.
Key Findings
In our survey of the apoptosis drug landscape, we identified 370 drugs aimed at 148 known gene targets.HSP90 (heat shock protein 90) is numerically the most popular target overall.
Seventy-six percent of all apoptosis-modulating drugs in development are anticancers, including 27 radio/chemosensitizers (7%). The overall apoptosis market is forecast to grow from $28 billion in 2008 to $57 billion in 2013.
• Of particular interest are first-in-class direct apoptogens (over 100 agents identified) which target elements of the apoptotic pathway (over 40 genes). The global market for direct apoptogens is forecast to grow from $606 million in 2008 to $12 billion in 2013.
• The leading subgroups of the direct apoptogens market are: proteasome inhibitors; modulators of heat shock proteins; TP53-targeted agents; caspase-targeted agents: BCL2-targeted agents; and multi-target apoptogens.
• Eighteen percent (65) of all apoptosis-modulating drugs in development are anti-inflammatory, and 6% (24) are CNS targeted. Our survey of apoptosis-related patents suggests that future drugs will also target infectious disease.

Key Questions answered

• What types of apoptosis-modulating drugs are on the market?
• Which companies are leading the way in the development of apoptosis- modulating drugs?
• Which assays and biomarkers are increasingly used to define apoptosis during drug development?
• Why should all new anticancer drugs be screened for apoptotic effects?
• How is the apoptosis drug target landscape shaping up?
• What are the most popular targets of direct apoptogens in development for the treatment of cancer?
• How is the global cancer apoptosis market segmented and how are these sectors expected to perform over the period 2008-13?
• What progress is being made in developing apoptosis-modulating drugs for the treatment of CNS diseases and inflammation/autoimmunity?
• What is the nature of the apoptosis-related patent landscape?

Table of Content

Front Cover
List of Tables and Figures
About Biophoenix
About the Authors
Legal Notice
Executive Summary

Chapter 1 Apoptosis and its regulation
1.0 Chapter summary
1.1 Introduction to apoptosis
1.2 Apoptosis versus necrosis
1.3 Other modes of cell death
1.3.1 Autophagy
1.3.2 Mitotic catastrophe
1.3.3 Anoikis
1.4 Mechanisms of apoptosis
1.5 Key molecular players in apoptosis
1.5.1 TNF family and death receptors
1.5.2 Apoptosis adaptor proteins
1.5.3 Caspases and other proteases
1.5.4 BCL2 family
1.5.5 IAPs and other regulators of caspases
1.5.6 Intracellular kinases
1.5.7 Transcription factors and regulators
1.6 Apoptotic pathways
1.6.1 Extrinsic pathway
1.6.2 Intrinsic pathway
1.6.3 The perforin/granzyme pathway
1.6.4 Execution pathway
1.7 Targeting dysregulated apoptosis
1.8 Apoptosis pipeline audit

Chapter 2 Assays and biomarkers of apoptosis
2.0 Chapter summary
2.1 Introduction
2.2 Analysis of cytomorphological parameters
2.3 Analysis of mitochondrial parameters
2.4 Biomarker-based assays of apoptosis
2.4.1 Commonly assayed biomarkers
2.4.1.1 Externalized phosphatidylserine
2.4.1.2 Nucleosomal DNA
2.4.1.3 Caspases
2.4.1.4 Cytochrome c
2.4.1.5 Other protein biomarkers
2.4.1.6 Cytokeratins (cancer)

Chapter 3 Indirect apoptogens in development for cancer
3.0 Chapter summary
3.1 Introduction to cancer
3.2 Overview of anticancer pharmacotherapies
3.3 Detecting apoptotic effects of new drugs
3.4 Drugs in development with apoptotic effects
3.5 First generation indirect apoptogens
3.5.1 Radio- and chemo-sensitizers
3.5.2 Alkylating and other DNA-binding agents
3.5.3 Antimetabolites
3.5.4 Topoisomerase inhibitors
3.5.5 Antitumor antibiotics
3.5.6 Microtubule-targeting agents
3.6 Second generation indirect apoptogens
3.6.1 Hormone antagonists
3.6.2 Biotherapies
3.6.2.1 Monoclonal antibodies
3.6.2.2 Ribonucleases
3.6.2.3 Peptides
3.6.2.4 Non-antisense oligonucleotides
3.6.2.5 Oncolytic viruses
3.6.2.6 Immunotherapies
3.6.3 Focus on kinase inhibitors

Chapter 4 Direct apoptogens in development for cancer
4.0 Chapter summary
4.1 Promoting apoptosis of cancer cells
4.2 Gene targets of apoptogens in development
4.2.1 TNF family and death receptors
4.2.1.1 TNFRSF10A
4.2.1.1.1 Description of target
4.2.1.1.2 Drugs in development
4.2.1.2 TNFRSF10B
4.2.1.2.1 Description of target
4.2.1.2.2 Drugs in development
4.2.1.3 TNFSF10
4.2.1.3.1 Description of target
4.2.1.3.2 Drugs in development
4.2.1.4 FAS
4.2.1.4.1 Description of target
4.2.1.4.2 Drugs in development
4.2.1.5 FASLG
4.2.1.5.1 Description of target
4.2.1.5.2 Drugs in development
4.2.1.6 TNFRSF1A
4.2.1.6.1 Description of target
4.2.1.6.2 Drugs in development
4.2.2 Caspases
4.2.2.1 CASP9
4.2.2.1.1 Description of target
4.2.2.1.2 Drugs in development
4.2.2.2 CASP3
4.2.2.2.1 Description of target
4.2.2.2.2 Drugs in development
4.2.3 BCL2 family
4.2.3.1 BCL2
4.2.3.1.1 Description of target
4.2.3.1.2 Drugs in development
4.2.3.2 BCL2L1
4.2.3.2.1 Description of target
4.2.3.2.2 Drugs in development
4.2.3.3 MCL1
4.2.3.3.1 Description of target
4.2.3.3.2 Drugs in development
4.2.3.4 BAD
4.2.3.4.1 Description of target
4.2.3.4.2 Drugs in development
4.2.4 IAPs and regulators
4.2.4.1 XIAP
4.2.4.1.1 Description of target
4.2.4.1.2 Drugs in development
4.2.4.2 BIRC3
4.2.4.2.1 Description of target
4.2.4.2.2 Drugs in development
4.2.4.3 BIRC5
4.2.4.3.1 Description of target
4.2.4.3.2 Drugs in development
4.2.4.4 DIABLO
4.2.4.4.1 Description of target
4.2.4.4.2 Drugs in development
4.2.4.5 CFLAR
4.2.4.5.1 Description of target
4.2.4.5.2 Drugs in development
4.2.5 Transcription factors and regulators
4.2.5.1 NFKB1
4.2.5.1.1 Description of target
4.2.5.1.2 Drugs in development
4.2.5.2 TP53
4.2.5.2.1 Description of target
4.2.5.2.2 Drugs in development
4.2.5.3 HDM2
4.2.5.3.1 Description of target
4.2.5.3.2 Drugs in development
4.2.5.4 STAT3
4.2.5.4.1 Description of target
4.2.5.4.2 Drugs in development
4.2.6 Kinases in the PI3K/AKT pathway
4.2.6.1 PIK3CA/PIK3CD/PIK3CG
4.2.6.1.1 Description of target
4.2.6.1.2 Drugs in development
4.2.6.2 AKT1
4.2.6.2.1 Description of target
4.2.6.2.2 Drugs in development
4.2.6.3 BTK
4.2.6.3.1 Description of target
4.2.6.3.2 Drugs in development
4.2.6.4 PRKD1
4.2.6.4.1 Description of target
4.2.6.4.2 Drugs in development
4.2.7 Histone deacetylases
4.2.7.1 HDAC (1-5, -7, -8, and -11)
4.2.7.1.1 Description of target
4.2.7.1.2 Drugs in development
4.2.8 Other targets
4.2.8.1 IL24
4.2.8.2 AIFM1
4.2.8.3 RLN1
4.3 Proteasome inhibitors
4.4 HSP inhibitors

Chapter 5 Other apoptosis modulators in development
5.0 Chapter summary
5.1 CNS diseases
5.1.1 Apoptosis agents in development
5.1.1.1 Apoptosis antagonists
5.1.1.2 Apoptosis agonists
5.2 Chronic inflammation and autoimmunity
5.2.1 Apoptosis agents in development
5.2.1.1 Apoptosis agonists
5.2.1.2 Apoptosis antagonists
5.3 Other apoptosis agents in development

Chapter 6 Commercial Outlook: Patent and Market Analysis
6.0 Chapter Summary
6.1 Patent Analysis
6.1.1 Preamble
6.1.2 Uses of Patent Information
6.1.3 The Apoptosis Patent Dataset
6.1.4 Apoptosis Patents by Filing and Publication Years
6.1.5 Apoptosis Patents by Leading Assignees
6.1.6 Focus on Cytovia / Maxim / EpiCept
6.1.7 Apoptosis Patents by Forward Citations
6.1.8 Apoptosis Patents by Activity
6.2 Market Analysis
6.2.1 Preamble
6.2.2 Cancer
6.2.2.1 Disease burden
6.2.2.2 Anticancer drug landscape
6.2.3 Non-cancer apoptosis modulators
6.2.4 World pharmaceutical market
6.2.5 Market outlook for apoptotic drugs
6.2.5.1 Drug and Target Types
6.2.5.2 Focus on Velcade (bortezomib)
6.2.5.3 Focus on Gendicine
6.2.5.4 Direct apoptogens
6.2.5.5 Indirect apoptogens

Chapter 7 Trends and opportunities
7.0 Chapter summary
7.1 Apoptosis modulation offers varied opportunities
7.2 New directions in cancer drug development
7.3 Combinatorial approaches to cancer drug resistance
7.4 Focus on apoptosis-resistant cancer stem cells
7.5 Key role for biomarkers of apoptosis in cancer
7.6 Prospects for apoptosis modulators in other areas
Appendix 1 Abbreviations and Acronyms
A1.1 Key gene targets for apoptotic modulation
A1.2 Other scientific/medical terms
A1.3 Institutions
Appendix 2 Research Methodology
Appendix 3 List of Tables and Figures

Related Reports

http://www.biotech-market-reports.com/market-reports/mesenchymal-stem-cells-advances-and-applications/
http://www.biotech-market-reports.com/market-reports/pharmacodynamic-assays/
http://www.biotech-market-reports.com/market-reports/global-injectable-drug-delivery-market/

About Us
BiotechMarketReports comprises an online library of 10,000 reports, in-depth market research studies of over 5000 micro markets, and 25 industry specific websites. Our client list boasts almost all well-known publishers of such reports across the globe. We as a third-party reseller of market research reports employ a number of marketing tools, such as press releases, email-marketing and effective search-engine optimization techniques to drive revenues for our clients. We also provide 24/7 online and offline support service to our customers.

Contact:
Ms. Sunita
7557 Rambler road,
Suite 727, Dallas, TX 75231
Tel: +1-888-989-8004
http://www.biotech-market-reports.com/

For more information on this press release visit: http://www.releasewire.com/press-releases/release-3.htm

Clinical Laboratory Services (Markets, Growth Opportunities, Competitive Analysis and Competitor Profiles), provides an in-depth market overview, a total market analysis, analysis by laboratory type, and by routine and specialty testing and a review of the latest trends driving growth. Revenues and forecasts presented are for the U.S. market. Key international markets are discussed as well.

Dallas, TX -- (SBWIRE) -- 03/29/2010 -- Biotech-Market-Reports Announce it Will Carry the Clinical Laboratory Services Market (Growth Opportunities, Competitive Analysis and Competitor Profiles) Market Research Report in its Store.

Browse the complete Report on: http://www.biotech-market-reports.com/market-reports/clinical-laboratory-services-market-growth-opportunities-competitive-analysis-and-competitor-profi/

Clinical laboratories are an essential part of the health industry. It is estimated that approximately 80% of physician's diagnoses are a result of laboratory tests. The constant pressure to reduce healthcare spending is shifting healthcare utilization in favor of the laboratory, making it an ever more valuable part of the treatment plan. As hospital stays are shortened, contact between the physician and patient is reduced, which places a larger role on labs to gather, interpret, and deliver accurate information to the physician in a timely manner. We can expect to see an increase in the number of clinical labs, particularly in the independent sector, as these trends continue to influence the industry.

Since the last time Kalorama Information studied this market two years ago, there have been substantial changes in the industry, including changes in market share as major companies eat into regional labs, new competitors enter the marketplace, and new specialty tests are developed and priced.
Clinical Laboratory Services (Markets, Growth Opportunities, Competitive Analysis and Competitor Profiles), provides an in-depth market overview, a total market analysis, analysis by laboratory type, and by routine and specialty testing and a review of the latest trends driving growth. Revenues and forecasts presented are for the U.S. market. Key international markets are discussed as well.

Key market data provided includes:
• Hospital, Physician and Independent Lab Statistics
• Major Tests Performed by Clinical Lab Companies
• Disease Incidence and Trends Driving Lab Business
• Market Forecast to 2014
• Market Breakdown by Lab Type (Hospital, Physician, Independent)
• Market Breakdown by Test Type (Specialty, Routine)
• Market Share of Competitors
• Competitive Analysis of Leading clinical Lab Providers

The issues and trends which are fueling growth:
A trend towards preventive and risk factor testing has been noted in several disciplines, particularly in the areas of oncology, endocrinology, and gynecology. Physicians in these areas are taking full advantage of testing for early detection and disease prevention. Some of the other issues and trends explored in this study include:

• U.S. Demographics
• Types of Specialty Tests
• Growing Competition
• Increasing Life Expectancy
• Growing Incidence of Disease
• New Product Offerings
• Regulatory Environment
• Insurance and Reimbursement
• Payer Types
• Developments in Personalized Medicine

A competitive analysis of leading clinical laboratory providers includes:
• Quest Diagnostics, Inc.
• Laboratory Corporation of America (LabCorp)
• Genomic Health
• Genoptix, Inc.
• Genzyme Corporation
• DaVita
• Clarient, Inc.
• Spectra Laboratories
• Bio-Reference Laboratories

Our methodology:
The information in this report is the result of interviews with executives and market experts, as well as thorough research of secondary sources such as company literature, trade publications and medical and business journals. The emphasis Kalorama puts on primary research guarantees that new insights will be uncovered that are not available from any other source. The most important part of Kalorama's efforts is its superior analysis of company activities and their true significance in the marketplace.

All market data pertains to the world market at the manufacturers' level. The base year for data was 2009. Historical data was provided for the years 2006, 2007 and 2008, with forecast data provided for 2010 through 2014. Compound annual growth rates (CAGRs) are provided for the 2006-2009 and 2009-2014 periods for each segment covered. A competitive analysis is provided for the year 2009. The forecasted market analysis for 2010-2014 was largely based on demographic trends, new developments, company performance trends, mergers and acquisitions, and national expansion.

CHAPTER ONE: EXECUTIVE SUMMARY

Industry at a Glance

Scope and Methodology

Size and Growth of the Market

Key Issues and Trends Affecting the Market

Leading Market Participants

CHAPTER TWO: INDUSTRY OVERVIEW, REGULATION AND TRENDS

Clinical Laboratory Description

Testing and Services

Routine Testing

Blood Cell Count

Cholesterol Level Testing

HIV Testing

Anti-HIV-1 Oral Specimen Collection Device

Anti-HIV-1 Testing Service

Nucleic Acid Testing

Human Immunodeficiency Virus Type 1 (Anti-HIV-1 Assay)

Human Immunodeficiency Virus Types 1 & 2 (Anti-HIV-1/2 Assay)

Pap Testing

Pregnancy Testing

Substance Abuse Testing

Urinalysis

Specialty Testing

Endocrinology

Esoteric Testing

Genetics

Immunology and Molecular Microbiology

Oncology

Serology

Toxicology

Industry Structure

Hospital-based Laboratories

Physician-office Laboratories

Independent Clinical Laboratories

Incidence of Diseases

Demographics

Population Over Age 65

Life Expectancy

Regulatory Overview

Certificate of Waiver

Certificate of Provider-Performed Microscopy Procedures (PPMP)

Certificate of Compliance and Certificate of Accreditation

States Exempt from Federal Clinical Laboratory Improvements Amendments (CLIA) of 1988

Insurance and Reimbursement

Laboratory Service Payer Types

Trends in Medicare Reimbursement

Commercial Insurance Providers

New Developments in Information Technology

International Markets and Trends

CHAPTER THREE: LEADING MARKET PARTICIPANTS

Summary

Quest Diagnostics, Inc.

Company Overview

Performance Review

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Business Locations

Laboratory Corporation of America

Company Overview

Performance Review

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Locations

Genzyme Corporation

Company Overview

Performance Review

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Locations

DaVita, Inc.

Company Overview

Performance Review

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Locations

Clarient, Inc.

Company Overview

Performance Review

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Locations

Spectra Laboratories

Company Overview

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Locations

Bio-Reference Laboratories

Company Overview

Performance Review

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Locations

Genomic Health, Inc.

Company Overview

Performance Review

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Locations

Genoptix, Inc.

Company Overview

Performance Review

Key Acquisitions, Alliances, and Partnerships

Products and Services

Growth Strategy

Locations

CHAPTER FIVE: MARKET ANALYSIS

Market Overview

Market Analysis by Laboratory Type

Market Analysis by Test Type

Competitive Analysis

APPENDIX: COMPANY DIRECTORY

Related Reports
http://www.biotech-market-reports.com/market-reports/world-market-for-molecular-diagnostics-the/
http://www.biotech-market-reports.com/market-reports/world-market-for-gastrointestinal-endoscopy-equipment-the/
http://www.biotech-market-reports.com/market-reports/us-markets-for-emr-electronic-medical-records-technology/

About BiotechMarketReports
BiotechMarketReports comprises an online library of 10,000 reports, in-depth market research studies of over 5000 micro markets, and 25 industry specific websites. Our client list boasts almost all well-known publishers of such reports across the globe. We as a third-party reseller of market research reports employ a number of marketing tools, such as press releases, email-marketing and effective search-engine optimization techniques to drive revenues for our clients. We also provide 24/7 online and offline support service to our customers.

Contact:
Ms. Sunita
7557 Rambler road,
Suite 727, Dallas, TX 75231
Tel: +1-888-989-8004
http://www.biotech-market-reports.com/

For more information on this press release visit: http://www.releasewire.com/press-releases/release-3.htm